Introduces principles and application of fluid and mass transport processes in cell, tissue and organ systems. Topics include intro to physiological fluid mechanics in the circulation and tissue, fundamentals of mass transport in biological systems, effects of mass transport and biochemical interactions at the cell and tissue scales and fluid and mass transport in organs. Prerequisites: APMA 2130 or MATH 3250, or APMA 2501 - Differential Equations & Linear Algebra, and BME 2101, and BME 2104, or instructor permission.

Provides students with the skills necessary to engage in meaningful engineering design, and focuses on the latter stages of the engineering design process - detailed design, prototyping, and evaluation. Students develop skills in computer assisted design, embedded controls, prototyping, analysis and teamwork. A major focus of the class is the execution of a design project. Prerequisites: PHYS 1425, and BME major or minor. Recommended Corequisite: PHYS 2415 or ECE 2200.

Students will design treatment strategies for cancer and cardiovascular disease based on molecular bioengineering principles. Special topics will include design of nanoparticle drug and gene delivery platforms, materials biocompatibility, cancer immunotherapy, and molecular imaging. Prerequisite: BME 2102 and BME 2315 or instructor permission. Recommended prerequisite: BME 2104 or BME 4414.

Presents analytical tools used to model signals & linear systems. BME examples include multicompartment modeling of drug delivery, modeling of dynamic biomechanical systems & electrical circuit models of excitable cells. Topics: signals & systems, convolution, continuous time Fourier transforms, electrical circuits & applications of linear system theory. Prerequisite: PHYS 2415 & APMA 2130, & CS 1110 or equivalent

Introduces techniques for constructing predictive or analytical engineering models for biological processes. Teaches modeling approaches using example problems in transport, mechanics, bioelectricity, molecular dynamics, tissue assembly & imaging. Problem sets include 1) linear systems and filtering 2) compartmental modeling 3) numerical techniques 4) finite element / finite difference models and 5) computational automata models. Prereq: CS 1110 or CS 1111 or CS 1112 or CS 1113. Co-requisites: APMA 2120 or MATH 2310 or MATH 2315 or instructor permission.

Introduces the fundamental principles of tissue engineering. Topics: tissue organization and dynamics, cell and tissue characterization, cell-matrix interactions, transport processes in engineered tissues, biomaterials and biological interfaces, stem cells and interacting cell fate processes and tissue engineering methods. Examples of approaches for regeneration of cartilage, bone, ligament, tendons, skin and liver are presented. Prerequisites: APMA 2130 or MATH 3250 or APMA 2501 - Differential Equations & Linear Algebra, and BME 2101, and BME 2104, or instructor permission.

Introduces principles of continuum mechanics of biological tissues & systems. 1) Review results used in biomechanics field, 2) properties of living tissue; 3) mechanical basis & effects of pathology & trauma: 4) intro to mechanotransduction, circulatory transport, growth & remodeling & tissue-engineered materials; 5) low Reynolds number flows in vivo & microsystems. Prerequisites: APMA 2120 or MATH 2310 or MATH 2315 and BME Major or Minor

Introduces the physiology of the kidney, salt and water balance, gastrointestinal system, endocrine system, and central nervous system, with reference to diseases and their pathophysiology. Prerequisite: (CHEM 1410 or CHEM 1610 or CHEM 1810) AND (PHYS 1425 or PHYS 1420 or PHYS 1710) AND BME 2101, or instructor permission.

Second part of a year-long course integrating concepts and skills from prior courses to formulate and solve problems in biomedical systems, including experimental design, performance and analysis. Prerequisite: 3rd Year standing in BME major, or instructor permission

Second half of a year-long design project required for BME majors. Students select, formulate, & solve a design problem related to a device or a system. Projects use conceptual design, skills obtained in the integrated lab & substantial literature and patent reviews. Projects are sponsored by faculty, physicians and/or companies. Students may work on their own with outside team members when appropriate or with other students in integrative teams. Prerequisite: 4th year standing in the Biomedical Engineering major or instructor permission.