Biology

This course introduces students to scientific-based discovery of how molecular dysfunction leads to disease. It also exposes them to the most current tools used in biomedical research to find novel genes and compounds that could help treat human disease. The course includes discovery-oriented lab, workshops, and lectures. Prerequisite: BIOL3000 and BIOL3010

The human body maintains stable energy levels, hydration, and temperature despite the challenges of ever-changing external environment, a process known as homeostasis. This course explores biological models and mechanisms of homeostasis, including how survival needs are monitored and met through changes in behavior and physiology. Students will gain a state-of-the-art perspective on homeostatic biology and its research methods and technology.

In this course, we'll dive into our current understanding of the evolution and ecology of parasitic interactions through primary literature, modeling, and experimental design. Throughout, we will focus on generating and testing hypotheses, evaluating theoretical models with evidence, drawing parallels between diverse domains of life, and connecting evolutionary and ecological ideas to today's past, present, and future epidemics.

The course will deep dive into what stem cells are, what they do, where and how they function, and how we can use stem cells in the clinic to repair damaged tissue and restore tissue function. The course will consist of a series of lectures and student run discussions related to current scientific literature.

Animals are incredibly diverse, but they all evolved from the same single-celled ancestor that lived hundreds of millions of years ago. This course takes a cell-biological approach to explore key questions in animal evolution such as the origins of multicellularity and differentiation. Students will gain a cutting-edge perspective on current research that integrates cell, developmental, and evolutionary biology to explore animal origins.

This course addresses the impact of the human genome project on understanding human genetic disease, focusing on the invaluable role for animal models of diseases in augmenting evaluation of genomic information to develop strategies for precision medicine. Animal models are an invaluable asset in reaching this goal because they allow experimental manipulations that go far beyond what is possible in human patients.

One of the most important characteristics of life is the ability to reproduce. In order to produce new life, multicellular organisms evolved specialized cells whose only purpose is reproduction ¿ the germ cells. Germ cells are the only cells that persist from one generation to the next and are often called immortal. We will decipher how these totipotent stem cells function in order to faithfully create the next generation of organisms.

Microbes rule. This course will teach microbial genomics using the cutting edge next-generation DNA sequencing technology and its applications to study microbes around us. Topics covered include microbial genomics, DNA sequencing and sequence analysis.

This course begins with discussion of pharmacological principles and normal function of the nervous and endocrine system. As we continue, we will describe how exogenous substances derived from plants (like drugs) impact the nervous system to restore normal or near-normal function, or alter normal function, in humans. The use of agents from plants in the alleviation of depression and anxiety will be emphasized.

The evolutionary history of a population can be studied by examining patterns of genetic variation among individuals. Using information about genetic variation, we can infer historical evolutionary events like migration and adaptation. In this lab course, you will learn to utilize genomic data to conduct evolutionary inference. We will learn fundamentals of population genetics, bioinformatic skills, and research methods applied to real short-read sequencing data.

This course will provide an in-depth exploration of the field of regenerative biology, focusing on the molecular and cellular mechanisms underlying tissue regeneration and repair in animals. We will explore the cellular basis of different types of regeneration and search for shared molecular mechanisms. With an eye towards the future, we¿ll also explore the implications for advancing regenerative medicine.

This course introduces students to foundational and modern neuroscience research techniques through laboratory investigations. Neuroscience is explored at the molecular, systems, and behavioral level. Topics covered include neuroanatomy, electrophysiology, biopotentials, development, histology, and microscopy. An emphasis is placed on structure-function relationships, experimental design, and application of techniques in research.

Introduces students to experimental approaches, including mammalian cell culture, gel electrophoresis, western blotting and immunofluorescence microscopy, that are used to study both normal and pathological processes at the level of individual cells. The biological theme of the course will be Alzheimer's disease (AD) and related neurodegenerative disorders. One laboratory lecture and one afternoon laboratory per week. Prerequisite: BIOL 3000

This course for advanced undergrads focuses on Alzheimer's disease research. The first 3 weeks are didactic. The remainder of the course emphasizes a "journal club¿ format where teams of students lead research paper discussions. Assessment: how well students lead/ participate in journal club discussions, periodic quizzes, and a final exam. Requirements: Students must have completed BIOL 3000 AND BIOL 3050 or PSYC 2200 or PSYC 3200. Anti-Requisite: BIOL 4559 topic: Neurodegenerative Diseases.

Introduction to experimental methods in neural development research using zebrafish as a model system. Lectures focus on vertebrate nervous system development and teratogens. Labs build skills in brightfield and fluorescence microscopy, morphological and behavioral analysis, and histology. Course begins with guided inquiry labs and progresses to student-developed scholarly research projects, culminating in presentations of novel research findings.

The goal of this course is to provide an original, unknown outcome research experience in developmental biology. After training in basic methods and descriptions of selected research problems, students form teams and investigate a problem of their choosing. Team members work together in the lab, but each writes an independent research proposal, a notebook, and a final project report on which they are graded. Recommended prerequisites: BIOL 3000 and 3010.

From plants to humans, hormones shape various aspects of organismal form and behavior over contemporary and evolutionary time. Delve into endocrine pathways, hormones' influence on development, and their role in coordinating responses to environmental and physiological stimuli. Gain a deep understanding endocrinology theories, concepts, and methods, and the ability to critically evaluate hormonal impacts on ecosystem and human health.

The mathematical foundations of population dynamics and species interactions as applied to population and community ecology and problems in conservation biology. One semester of calculus is recommended. Prerequisite: BIOL 3020 or EVSC 3200

Aging is an evolutionary paradox because it decreases physiological function and increases the risk of mortality, yet aging persists in most species. We will explore the theories of aging and the diversity of the patterns of aging across species from flies to plants to humans. We will use the primary literature in the fields of evolution, genetics and cell biology to gain a comprehensive understand of the latest advances in this field.

Despite the many benefits of asexual reproduction, the vast majority of eukaryotic organisms reproduce sexually. How sex evolved, and how it persists despite its many associated costs, are major unanswered questions in biology. We will explore the diversity of sexual reproduction and associated evolutionary phenomena with a focus on critically evaluating current research and theory in this field.Prerequisite: BIOL 3020 or permission from Instructor

Introduces biological timekeeping as used by organisms for controlling diverse processes, including sleep-wakefulness cycles, photoperiodic induction and regression, locomotor rhythmicity, eclosion rhythmicity, and the use of the biological clock in orientation and navigation. Prerequisite: BIOL 3000 or 3010 or 3020

Why do some diseases become global pandemics, while others die out? What happens to a food web when a species goes extinct? What roles do different organisms have within a social network? How does the structure of brain networks relate to cognitive function? Networks are all around us; we just need to learn to see them. This course will introduce network analysis as a tool for answering fundamental and applied questions across biological disciplines. Coding experience is strongly recommended.

Focuses on the fundamental knowledge about organization, expression, and inheritance of the human genome. Reviews classical Mendelian genetics and human genetic (pedigree) analysis. Emphasizes understanding human genetics in molecular terms. Includes gene mapping procedures, methodologies for identifying genes responsible for inherited diseases, the molecular basis of several mutant (diseased) states, the human genome project, and discussions about genetic screening and gene therapy. Prerequisite: BIOL 3010.

This course uses a case study approach to examine cellular processes that underlie diverse diseases and to identify the relevant molecular components that have been validated or that may serve as new therapeutic targets. We will discuss both established, transformative drugs as well as novel, emerging therapies under development. We will consider socio-economic and demographic issues that impact the accessibility and affordability of new drugs.

This laboratory course provides hands-on experiences with experimental approaches used to study animal behavior. The laboratory exercises explore visual and auditory sensory perception, biological clock, reproductive and aggressive behaviors using actively behaving animals such as hamsters, cichlid fish, crickets and electric fish. Students are given opportunities to design hypothesis-testing experiments in some laboratories.